Lenzetto

Lenzetto is an oestrogen-only hormone replacement therapy (HRT), treatment that replaces hormones that fall during menopause. It delivers estradiol, a form of oestrogen, through your skin using a measured spray.

This guide covers Lenzetto 1.53mg/spray transdermal spray. Use your prescribed number of sprays once a day. Prevent skin contact with the treated area for at least 60 minutes, and keep away from flames until the spray is completely dry. If you still have your womb, you must also use a separate progestogen — a hormone that protects your womb lining — as prescribed.

Always follow your prescription and read the patient information leaflet supplied with your treatment.

Lenzetto 1.53 mg/spray Transdermal Spray is an oestrogen-only hormone replacement therapy (HRT) that is delivered as a transdermal (through the skin) spray, and in this way is also absorbed directly into the bloodstream. Its active ingredient is estradiol (as estradiol hemihydrate), which is a body-identical form of the female hormone oestrogen, meaning it is chemically the same as the oestrogen the body produces naturally.

Lenzetto is used for the relief of postmenopausal symptoms such as hot flushes, night sweats, mood swings, and vaginal dryness.

Progestogen Requirement: If you have a womb, you must also take a separate progestogen to protect your womb lining. Speak to your clinical team for further advice if you are unsure.

You may notice an improvement in symptoms within a few weeks, but it can take up to three months to adjust and feel the full benefit. Speak to your clinical team if symptoms aren’t improving.

Before using a new applicator for the first time, you must prime it by spraying three times into the cap. This only needs to be done once per device. The spray should be applied once daily, at the same time each day.

To apply a dose:

You should also use Lenzetto with caution in extreme temperature conditions, such as sunbathing or saunas. Speak to your clinical team for further advice if you are unsure.

If a dose is missed, you should make up for the missed dose as soon as you remember, and take the next dose at the usual time. If it is almost time for the next dose, you should skip the missed dose and take the next dose at the usual time. If one or more doses are missed, one primer spraying with the cover on is needed.

Forgetting a dose may increase the likelihood of unexpected bleeding and spotting.

If you do miss one or more doses, prepare the applicator according to the

instructions given in your Patient Information Leaflet (supplied with your treatment) under the section “If you forget to use Lenzetto”. Always follow your prescribed instructions and check with your clinical team if you’re unsure.

The usual starting dose of Lenzetto is one spray per day. If your symptoms don't improve after at least four weeks, your clinician may increase your dose to two, or a maximum of three, sprays per day. Your clinician will aim to use the lowest effective dose for the shortest time needed to manage your symptoms, with regular reviews.

There are no special dosage requirements for older patients, although experience in treating women over 65 is limited. This medicine is not for use in children.

Overweight and obese women: There is some limited data that the rate and extent of absorption of Lenzetto can be reduced in overweight and obese women. During your treatment, the dose of Lenzetto may require adjustment by your clinician if needed.

This treatment isn’t contraception. You may still need contraception, including if it’s been less than 12 months since your last period or you’re under 50. Ask your clinical team for advice tailored to you.

If you become pregnant, stop treatment immediately and contact your clinician. This treatment isn’t indicated during breastfeeding.

It is crucial to understand that if you have not had a hysterectomy (surgery to remove the womb) (i.e., you still have your womb), you must take a separate progestogen hormone (which protects the womb lining) alongside Lenzetto. This is typically prescribed for 12 to 14 days each month. This is a vital safety measure to protect the lining of your womb from the effects of oestrogen, which, when taken alone, can lead to a build-up of the lining (endometrial hyperplasia) and increase the risk of endometrial cancer (cancer of the womb lining).

Risk of Transference: The hormone in the Lenzetto spray can be accidentally transferred to other people through skin-to-skin contact. It is very important to prevent others, especially children and pets, from coming into contact with the application area. You should cover the treated area with clothing once the spray is dry and avoid contact for at least 60 minutes. There have been reports of children showing unexpected signs of puberty (like breast budding) after accidental exposure. If you suspect someone has been exposed, wash their skin with soap and water immediately and consult a doctor.

Flammability: Lenzetto is alcohol-based and is flammable. You must avoid fire, open flames, or smoking while applying the spray and until it has completely dried on your skin.

Common side effects of treatment with Lenzetto include skin irritation where the spray is applied, headache, abdominal pain, nausea, breast tenderness, and irregular vaginal bleeding. As a transdermal form of HRT, Lenzetto bypasses the liver and carries a lower risk of blood clots (venous thromboembolism) compared to other systemic forms of HRT, such as oral tablets or capsules. The other risks associated with systemic HRT, such as a small increased risk of breast cancer and stroke, still apply, although the overall risk remains low for most patients being treated. For a full list of side effects, please see the Patient Information Leaflet provided with your medication.

Your clinician will review your treatment after three months, then at least once a year. They’ll check your symptoms, side effects, any vaginal bleeding, your weight, and your blood pressure, and decide whether further tests are needed.

Examine your breasts regularly and attend routine screening appointments, including mammograms and cervical screening where appropriate. If you had menopause earlier than expected, discuss how this may affect the benefits and risks of HRT with your clinician.

Stop using Lenzetto and seek urgent medical advice if you develop:

If you have difficulty breathing or another life-threatening symptom, call 999. Don’t wait for an email response.

For planned changes or stopping treatment, speak to your clinician. They may recommend reducing your dose gradually to help prevent menopausal symptoms from returning suddenly.

Tell your clinical team if you have any of the following conditions, have had them before, or they worsened during pregnancy or previous hormone treatment. You may need closer monitoring because they can return or worsen during treatment.

Do not refrigerate or freeze. Do not store above 25°C. Use within 56 days of first use. Store away from heaters, open flames, and other sources of ignition. Keep out of reach of children.

Contact your clinical team if you have questions about your prescribed schedule, side effects, symptoms that aren’t improving, or bleeding that concerns you. For non-urgent questions or to discuss your clinical plan, email [email protected].

Yes. Cover the treated area once it’s dry and prevent contact for at least 60 minutes, especially with children and pets. If someone’s skin is accidentally exposed, wash it with soap and water immediately and consult a doctor.

No. Follow your prescription and speak to your clinical team before changing your dose or treatment schedule.

No. Ask your clinical team whether you still need contraception and which options are suitable for you.

Read the patient information leaflet supplied with your treatment for the full list of reasons not to use it, side effects, and precautions. This guide doesn’t replace that leaflet or your clinician’s instructions.