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What are the possible side effects of TRT?

Updated this week

Testosterone replacement therapy (TRT) can cause side effects, so it’s important to understand what to expect before starting treatment. Side effects can vary depending on the type of medication and how your body responds.

Common side effects:

  • Skin changes: acne or oily skin

  • Fluid retention

  • Increase in red blood cell count


Some men may also experience:

  • Breast changes: tenderness or enlargement

  • Mood and sleep: irritability or sleep disturbances

  • Libido changes


Fertility and Reproductive Health

  • TRT can reduce sperm production and, in some cases, lead to testicular shrinkage.


There is a potential increased risk of blood clots, and prostate health must be monitored throughout treatment.


The bottom line: Regular check-ups are essential to ensure treatment remains safe, balanced, and appropriate for you.

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